The second-ranked Michigan Wolverines (11-1) seek their first conference title since 2004 when they take on the No. 15 Iowa Hawkeyes (10-2) on Saturday night in the Big Ten Championship Game.

Kickoff from Lucas Oil Stadium in Indianapolis is set for 8 p.m. ET. The Wolverines are the 12-point favorites in the latest Michigan vs. Iowa odds from Caesars Sportsbook, while the over-under for total points scored is 43.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you decide on any Michigan vs. Iowa picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Michigan is 10-2 against the spread this season. The Wolverines are one of the most balanced teams in the nation, ranking in the top 25 in most areas on both sides of the ball. QB Cade McNamara (2,301 yards, 14 TDs) and RBs Hassan Haskins (1,232 yards, 18 TDs) and Blake Corum (865, 10) propel a dangerous offense. Haskins rushed for 169 yards in the monumental win against Ohio State. Aidan Hutchinson (13 sacks) and David Ojabo (11) will put the pressure on Iowa QB Spencer Petras all day.  

Iowa is 7-5 ATS this year and the underdog is 9-4 ATS in the last 13 meetings between the teams. The Hawkeyes were ranked as high as No. 2 this season and are led by a ferocious defense. The unit ranks 10th in the nation in allowing just 17.3 points per game and yields just 315.8 yards (13th). Linebacker Jack Campbell is a tackling machine (124, T-8 in FBS), and Joe Evans and Lukas Van Ness both have six sacks. Iowa has a nation-best 22 interceptions, led by Dane Belton (five) and Riley Moss (four).          

The SportsLine model has simulated Saturday's Iowa vs. Michigan Big Ten Championship matchup 10,000 times, and the results are in. We can tell you that the model is leaning Over on the total, and it also says one side of the spread is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Michigan vs. Iowa in Saturday's Big Ten Championship? And which side of the spread is hitting almost 60 percent of the time? ... Join SportsLine right now to find out which side of the Iowa vs. Michigan spread you should be all over Saturday, all from the computer model on a 42-28 run on its top-rated college football side picks!