The 2025 Big 12 Tournament will begin on Tuesday and one first-round matchup will pit the No. 9 seed TCU Horned Frogs against the No. 16 seed Colorado Buffaloes. TCU went 16-15 overall this season and was 9-11 in the Big 12 while Colorado has a 12-19 record with a 3-17 mark in the conference.

Tipoff is set for 3 p.m. ET at T-Mobile Center in Kansas City. The Horned Frogs are 2.5-point favorites in the latest TCU vs. Colorado odds from SportsLine consensus, while the over/under for total points scored is 133.5. 

Before making any Colorado vs. TCU picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated TCU vs. Colorado 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Colorado vs. TCU, and which side of the spread hits in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!