The Big 12 Tournament continues Wednesday when the Iowa State Cyclones take on the Cincinnati Bearcats in a second-round matchup. Iowa State is the No. 5 seed in the Big 12 after going 23-8 on the season and 13-7 in conference play. No. 12 seed Cincinnati is 18-14 overall and went 7-13 in the league before winning a first-round matchup over Oklahoma State.

Tipoff is set for 12:30 p.m. ET at T-Mobile Center in Kansas City. The Cyclones are 9.5-point favorites in the latest Iowa State vs. Cincinnati odds from SportsLine consensus, while the over/under for total points scored is 134.5. 

Before making any Cincinnati vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Iowa State vs. Cincinnati 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Cincinnati vs. Iowa State, and which side of the spread hits in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!