In a 2021 NCAA Tournament that has been rife with surprises, the No. 1 seed Baylor Bears and second-seeded Houston Cougars managed to avoid the upset bug to advance to a Final Four matchup on Saturday in Indianapolis.  

Tip-off at Lucas Oil Stadium is set for 5:14 p.m. ET on CBS. The winner advances to the national championship game on Monday to play either Gonzaga or UCLA. William Hill Sportsbook lists the Bears as five-point favorites, while the Over-Under for total points scored is 135 in the latest Baylor vs. Houston odds (see up-to-date lines for every game on our college basketball odds page). 

Before making any Houston vs. Baylor picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Baylor vs. Houston. We can tell you the model is leaning Over the total, and it also says one side of the spread hits almost 60 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Baylor vs. Houston? And which side of the spread hits almost 60 percent of the time? ... Join SportsLine right now to find out which side of the Houston vs. Baylor spread you should be all over Saturday, all from the model on a roll on college basketball picks!