The ninth-seeded Baylor Bears take on the top-seeded Duke Blue Devils in an East Region second-round matchup on Sunday. The Bears (20-14), who have compiled a 24-16 tournament record in 17 appearances, have lost in the second round in each of the last three NCAA Tournaments after winning the national championship in 2021. The Blue Devils (32-3), who are 123-41 in 47 tournament appearances, have made the Elite Eight 24 times, including twice in the past three seasons.

Tipoff from Lenovo Center in Raleigh, N.C., is set for 2:40 p.m. ET. Duke is a 12.5-point favorite in the latest Baylor vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 145.5. 

Before making any Baylor vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Baylor vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 50% of simulations!

So who wins Baylor vs. Duke, and which side of the spread hits in over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!