The shorthanded and top-seeded Duke Blue Devils will battle the second-seeded Louisville Cardinals for the Atlantic Coast Conference Tournament championship on Saturday. Duke held off a furious rally from fifth-seeded North Carolina 74-71 on Friday night in the semifinals, while Louisville defeated Clemson 76-73. The Cardinals (27-6, 18-2 ACC), who have won 11 in a row and 21 of 22 games, are 2-4 against ranked teams this season. The Blue Devils (30-3, 19-1 ACC), who will be without freshman forward Cooper Flagg (ankle), have won 10 straight and 26 of 27 games.

Tipoff from Spectrum Center in Charlotte, N.C., is set for 8:30 p.m. ET. Duke is a 6.5-point favorite in the latest Louisville vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 147.5.

Before making any Duke vs. Louisville picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters conference championship week on a 225-165 roll (+1873) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Duke vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in over 60% of simulations!

So who wins Duke vs. Louisville, and which side of the spread cashes in over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!