Two of the most prominent coaches in college basketball will go head-to-head with a trip to the Sweet 16 on the line when John Calipari and the No. 10 seed Arkansas Razorbacks take on Rick Pitino and the No. 2 seed St. John's in the second round of the 2025 NCAA Tournament on Saturday. Arkansas improved to 21-13 overall with a 79-72 win over No. 7 seeded Kansas Jayhawks, while St. John's improved to 31-4 after an 83-53 win over No. 15 Omaha in the opening round.

Tipoff from Amica Mutual Pavilion in Providence, R.I. is set for 2:40 p.m. ET. The Red Storm are 7.5-point favorites in the latest Arkansas vs. St. John's odds via SportsLine consensus, while the over/under for total points is 146.5.

Before making any Arkansas vs. St. John's picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Arkansas vs. St. John's 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Arkansas vs. St. John's , and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!