It's a Big 12 vs. SEC matchup on Saturday when the Oklahoma State Cowboys host the Arkansas Razorbacks. Both teams started off with wins and covers in Week 1 as Arkansas beat Arkansas-Pine Bluff 70-0, covering as a massive 50-point favorite. Oklahoma State beat South Dakota State 44-20, covering as a 12.5-point favorite. 

Kickoff is scheduled for noon ET at Boone Pickens Stadium. The Cowboys are 9.5-point favorites in the latest Oklahoma State vs. Arkansas odds via SportsLine consensus, while the over/under for total points scored is 61.5. (See up-to-date odds for every game on our college football odds page.)

Before making any Arkansas vs. Oklahoma State picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model knows that this is a make-or-break year for Arkansas head coach Sam Pittman. The Razorbacks had no problems handling a FCS foe in Week 1, and transfer quarterback Taylen Green had two rushing and two passing touchdowns.

Oklahoma State, meanwhile, rolled against South Dakota State. The Cowboys have one of the most dynamic players in the nation in running back Ollie Gordon II. With a more manageable Big 12 schedule this year, OK State is hoping to make a run at the expanded playoff field. 

For Saturday, the model has set its sights on Arkansas vs. Oklahoma State. We can tell you the model is leaning Under the total, projecting the teams to combine for 56 points. It also says one side of the spread hits in over 50% of simulations. You absolutely need to see it before locking in any college football picks.

Who wins OK State vs. Arkansas, and which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the spread you should be all over Saturday, all from the model that's returned more than $2k on its top-rated CFB picks against the spread!