The No. 1 seed Duke Blue Devils and the No. 4 seed Arizona Wildcats battle in the Sweet 16 on Friday. The Blue Devils have been dominant during this tournament, winning each game by at least 23 points. Duke blew out Baylor 89-66 on March 23. On the other side, Arizona defeated Oregon 87-83 in a second-round contest on March 23. 

Tip-off from the Prudential Center in Newark, N.J., is set for 9:39 p.m. ET. Duke is a 9.5-point favorite in the latest Arizona vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 153.5. The Blue Devils are -488 money-line favorites. 

Before making any Arizona vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Arizona vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Arizona vs. Duke, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 25 double-digit upsets!