The No. 12 Duke Blue Devils will face the No. 17 Arizona Wildcats on Friday night in the first meeting between the schools in Tucson in more than two decades. Duke bounced back from a loss to then-No. 19 Kentucky with an 86-35 win over Wofford on Saturday, easily covering the spread as a 26-point favorite. Arizona is hoping to bounce back from its first loss of the season after falling to Wisconsin in a 103-88 final last Friday. 

Tipoff is set for 10:30 p.m. ET on Friday at McKale Memorial Center. Arizona is favored by 1.5 points in the latest Arizona vs. Duke odds, while the over/under is 160.5 points, per SportsLine consensus. Before entering any Duke vs. Arizona picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 3 of the 2024-25 season on a 156-114 betting roll (+1762) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps has seen HUGE returns!

The model has simulated Arizona vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 60% of simulations!

So who wins Arizona vs. Duke, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!