A pair of champions square off when Anthony Joshua meets unbeaten Oleksandr Usyk for the WBA (Super), IBF, WBO and IBO heavyweight titles on Saturday. The card is slated for a 1 p.m. ET start from Tottenham Hotspur Stadium in London.

Joshua enters the fight with a 24-1 record, including 22 wins by knockout. Usyk has not lost in 18 matches, which include 13 knockout victories.

Joshua, 31, retained his four belts last December when he knocked out Kubrat Pulev at 2:58 of the ninth round. He had dropped Pulev twice in the third round before ultimately ending the fight early. It was his first knockout win in over two years. 

Usyk has dominated the cruiserweight division since his first professional fight in September 2013, at age 26. He won all 16 bouts at that weight class before making the jump to heavyweight. On Oct. 12, 2019, he won his first heavyweight match when Chazz Witherspoon retired at three minutes of the seventh round. He followed that up with a 12-round unanimous decision victory over Derek Chisora last October, to win the WBO Inter-Continental heavyweight crown.    

Joshua is priced at -260 (risk $260 to win $100) in the latest Joshua vs. Usyk odds from Caesars Sportsbook, while Usyk is listed at +210. Before making any Joshua vs. Usyk picks, make sure you see the boxing predictions from SportsLine insider Brandon Wise.

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. His strong 2021 boxing record includes nailing the outcome of the much-anticipated fight between Jake Paul and Ben Askren. Wise told SportsLine members to expect an early knockout from Paul (-170), who delivered with a first-round overhand right against the hapless Askren (+150), who visibly stumbled after taking the referee's count. Anyone who has followed Wise's combat sports picks has seen massive returns. 

What's more, Wise also has been on point with his UFC predictions. He called Israel Adesanya by decision at +140 and Brandon Moreno to win outright at +190 at UFC 263 earlier this summer.

Now, with Saturday's showdown fast approaching, Wise has studied Joshua vs. Usyk from every angle, identified the best value in the boxing odds and released highly confident picks. Wise has made the call on which fighter wins and has locked in a strong prop pick that returns 3-1! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Anthony Joshua vs. Oleksandr Usyk on Saturday? And which prop is a MUST-BACK? ... Join SportsLine here to see which bets you need to make for Saturday's big fight, all from the accomplished combat sports analyst who has been profitable every year!