The top two teams in the East Region collide when the second-seeded Alabama Crimson Tide take on the top-seeded Duke Blue Devils in an Elite Eight matchup on Saturday. The Crimson Tide (28-8), who are in the Elite Eight for the second year in a row, are looking to make their second-ever Final Four, joining last year's team. The Blue Devils (34-3), who lost in the Elite Eight in 2024, are looking to reach the Final Four for the first time since 2022.

Tipoff from Prudential Center in Newark, N.J., is set for 8:49 p.m. ET. Duke is a 6.5-point favorite in the latest Alabama vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 175, up 3.5 points from the opener.

Before making any Alabama vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Alabama vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits more than 50% of the time!

So who wins Alabama vs. Duke, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 25 first-round upsets by double-digit seeds!