The 2025 ACC Tournament continues on Wednesday and one second-round matchup will pit the North Carolina Tar Heels against the Notre Dame Fighting Irish. North Carolina is 20-12 overall this season and earned the No. 5 seed in the conference tournament after going 13-7 in the ACC while Notre Dame (15-17, 8-12) is the No. 12 seed.

Tipoff is set for 2:30 p.m. ET at the Spectrum Center in Charlotte, N.C. The Tar Heels are 10.5-point favorites in the latest North Carolina vs. Notre Dame odds from SportsLine consensus, while the over/under for total points scored is 144.5. 

Before making any Notre Dame vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters  conference championship week on a 225-165 roll (+1873) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated North Carolina vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in almost 60% of simulations!

So who wins Notre Dame vs. North Carolina, and which side of the spread hits in nearly 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!