We've got another exciting Eastern Conference matchup on Wednesday's NBA schedule as the Philadelphia 76ers will host the Cleveland Cavaliers. Philadelphia is 2-8 overall and 1-4 at home, while Cleveland is 12-0 overall and 6-0 on the road. The teams split their four matchups last season, including splitting the two in Philadelphia.

Tip-off is at 7:30 p.m. ET at Wells Fargo Center in Philadelphia. Cleveland is favored by 9.5 points in the latest 76ers vs. Cavaliers odds, per SportsLine consensus, and the over/under is 218.5 points. Before entering any Cavaliers vs. 76ers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 4 of the 2024-25 NBA season on a sizzling 106-70 roll on all top-rated NBA picks dating back to last season, returning more than $3,000. Anyone following at sportsbooks and on betting apps has seen huge returns.

The model has simulated Sixers vs. Cavs 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits over 50% of the time. You can only see the pick at SportsLine.

So who wins 76ers vs. Cavaliers, and which side of the spread hits in over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.