The Philadelphia 76ers will try to continue their quest to earn the top spot in the Eastern Conference standings when they host the Cleveland Cavaliers in a key NBA game on Friday at the Wells Fargo Center in Philadelphia. The 76ers (38-23) enter Friday tied for the second best record in the East, 2.5 games behind the conference-leading Miami Heat. Meanwhile the Cavaliers (36-26) sit in sixth in the East, five games behind Miami. Tip-off is at 7 p.m. ET. Philadelphia is listed as a seven-point favorite in the latest 76ers vs. Cavaliers odds from Caesars Sportsbook while the Over/Under for total points scored is 216.5. 

Before making any Cavaliers vs. 76ers picks or NBA predictions, see what SportsLine's advanced computer model has to say. (Check out the odds of every game on SportsLine's NBA odds page.)

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 19 of the 2021-22 NBA season on a stunning 71-44 roll on all top-rated NBA picks, returning more than $2,100. Anyone following it has seen HUGE returns.

The model knows that Philadelphia has been dominant since James Harden joined the team. In three games since the future Hall of Famer joined the 76ers, they have earned three blowout wins (one over the Timberwolves and two over the Knicks). Philadelphia's average margin of victory during that three-game stretch was 20.7 points a game.

The model also knows that Cleveland is one of the best defensive teams in the league. Anchored by the defense of rookie Evan Mobley, the Cavaliers give up just 103.0 points per game, which leads the NBA. They also rank fourth in defensive efficiency (106.3 points allowed per 100 possessions).

Now, the model has simulated 76ers vs. Cavaliers 10,000 times, and the results are in. We can tell you that the model is leaning Under the total, predicting a combined 216 points, and it also says one side of the spread covers almost 60 percent of the time. You absolutely need to see it before locking in your own picks.

Who wins 76ers vs. Cavaliers? And which side of the spread covers in almost 60 percent of simulations? Join SportsLine right now to see which side of the Cavaliers vs. 76ers spread you need to jump on, all from the computer model that has crushed its NBA picks.