The Minnesota Vikings (2-4) will host the San Francisco 49ers (5-1) in an NFC tilt on Monday Night Football. The 49ers are coming off their first loss of the season, falling to the Cleveland Browns, 19-17. Meanwhile, Minnesota topped the Chicago Bears 19-13 last week. 49ers receiver Deebo Samuel is out with a shoulder injury, while running back Christian McCaffrey (oblique) is questionable.

The game will kick off at 8:15 p.m. ET. San Francisco is a seven-point favorite in the latest 49ers vs. Vikings odds, while the over/under for total points scored is 43. Before you make any 49ers vs. Vikings picks of your own, you NEED to see what SportsLine NFL expert Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. Those selections formed the basis of his SportsLine NFL best bets article, which finished 36-25-1. 

In addition, Hartstein has gone an AMAZING 40-16-2 on his last 58 picks involving the Vikings, returning $2,176! Anyone who has followed him is WAY UP.

Now, Hartstein has locked in another confident against-the-spread pick for 49ers vs. Vikings. We can tell you he's leaning Under the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins 49ers vs. Vikings on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the 49ers vs. Vikings spread to jump on Monday, all from the expert on a 40-16 roll on picks involving Minnesota!