The San Francisco 49ers will tie the NFC West Division lead with a home win on Sunday against the Seattle Seahawks. San Francisco (5-4) enters off a 23-20 last-second road victory over Tampa Bay, while Seattle enters off a bye following a 26-20 overtime loss to the Rams. The 49ers won this matchup on the road in Week 6, 36-24. San Francisco is 4-5 against the spread, while Seattle is 2-6-1 ATS in 2024.

Kickoff from the Levi's Stadium is set for 4:05 p.m. ET. San Francisco is a 6.5-point favorite in the latest 49ers vs. Seahawks odds via SportsLine consensus, while the over/under for total points is 48. The 49ers are -270 money line favorites (risk $270 to win $100). Before making any Seattle vs. San Francisco picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2024 NFL season on an incredible 17-7 hot streak on top-rated NFL picks this year. Longer term, it is on a 197-136 roll on top-rated NFL picks that dates back to the 2017 season and a 51-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated 49ers vs. Seahawks 10,000 times and the results are in. We can tell you the model is leaning Over on the total. It also says one side of the spread hits nearly 60% of the time!

Who wins Seattle vs. San Francisco, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!