The San Francisco 49ers (9-4) will try to clinch the NFC West title with their seventh consecutive victory when they visit the division-rival Seattle Seahawks (7-6) on Thursday Night Football. San Francisco, which posted a 27-7 home win against Seattle in Week 2, leads the Seahawks by two games with four remaining. The 49ers rolled to a 35-7 triumph over visiting Tampa Bay last Sunday behind rookie quarterback Brock Purdy, who made his first career start due to injuries to Trey Lance (ankle) and Jimmy Garoppolo (foot). Seattle is coming off its third loss in four contests, a 30-24 home setback against Carolina.

Kickoff at Lumen Field is set for 8:15 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 43. Before making any Seahawks vs. 49ers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Purdy, who was the 262nd and final pick of this year's NFL Draft, has completed 70.7% of his pass attempts with four touchdowns and one interception since replacing Garoppolo in Week 13. The 22-year-old became the first quarterback since Marc Bulger in 2002 to record a passer rating of at least 130, two TD tosses and a rushing score in his first career start.

The model also knows the Seahawks have struggled against the run, ranking 31st at 160.5 yards allowed per game. They have yielded an NFL-worst average of 209.5 yards over their last four contests. Quarterback Geno Smith has thrown at least two touchdown passes in seven consecutive games and 11 of his 13 outings this season.

Now, the model has set its sights on 49ers vs. Seahawks on Thursday Night Football. We can tell you the model is leaning Over the total, and it also says one side of the spread cashes in over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins 49ers vs. Seahawks on Thursday Night Football? And which side of the spread hits over 50% of the time? Join SportsLine now to see which side of the Seahawks vs. 49ers spread to back, all from the model that's an amazing 157-113 on NFL picks!