Teams looking to turn their recent fortunes around will clash when the San Francisco 49ers face the Seattle Seahawks in a key NFC West matchup on Thursday Night Football. San Francisco is coming off a 24-23 loss to the Arizona Cardinals, while Seattle dropped a 29-20 decision to the New York Giants at home. Kickoff from Lumen Field in Seattle is set for 8:15 p.m. ET.

San Francisco is a 3.5-point favorite, while the over/under for total points scored is 49 in the latest 49ers vs. Seahawks odds from the SportsLine Consensus. The 49ers are -193 money-line favorites (risk $193 to win $100), while the Seahawks are +161 underdogs. Before making any 49ers vs. Seahawks picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, the model has set its sights on 49ers vs. Seahawks. We can tell you the model is leaning Over the total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins 49ers vs. Seahawks on Thursday Night Football? And which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the 49ers vs. Seahawks spread is a MUST-BACK, all from the model on a 45-23 roll on NFL picks!