The San Francisco 49ers look to bounce back after a surprising road loss as travel south to face their NFC West rivals, the Los Angeles Rams on Sunday afternoon. The 49ers (1-1) fell in Minnesota, 23-17, while the Rams (0-2) got crushed by Arizona, 41-10. The teams split a pair of meetings last year: a 30-23 49ers road win and a 21-20 Rams victory in Week 18.

Kickoff from SoFi Stadium is set for 4:25 p.m. ET. San Francisco is a 6.5-point favorite in the latest 49ers vs. Rams odds, while the over/under for total points is 44.5. The 49ers are -287 money-line favorites (risk $287 to win $100). Before making any Los Angeles vs. San Francisco picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated 49ers vs. Rams 10,000 times and the results are in. We can tell you the model is leaning Under on the total. It also says one side of the spread hits in more than 50% of simulations! You ABSOLUTELY need to see what it is before locking in any NFL picks of your own!

Who wins Rams vs. 49ers, and which side of the spread hits over 50% of the time? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!