The San Francisco 49ers (5-5, 2-2) hit the road looking to climb back into the NFL playoff picture when they take on the Green Bay Packers (7-3, 3-2) on Sunday at Lambeau Field. Both teams are 4-6 against the spread in 2024. The 49ers are coming off a 20-17 home loss to the Seattle Seahawks, while the Packers beat the Chicago Bears 20-19 thanks to a blocked field goal on the final play of the game. Brandon Allen will start in place of Brock Purdy (shoulder) for the Niners. 

Kickoff in Green Bay is at 4:25 p.m. ET. The Packers are favored by 5.5 points in the latest Packers vs. 49ers odds from SportsLine consensus, and the over/under is 44.5 points. Green Bay is the -249 money line favorite (risk $249 to win $100), while San Francisco is the +202 underdog. Before locking in any 49ers vs. Packers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2024 NFL season on an incredible 20-8 hot streak on top-rated NFL picks this year. Longer term, it is on a 200-136 roll on top-rated NFL picks that dates back to the 2017 season and a 54-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated 49ers vs. Packers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Packers vs. 49ers, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model on a 20-8 run on its NFL picks, and find out!