The Philadelphia Eagles own the NFL's best record and look to strengthen their lead in the race for the No. 1 overall seed in the NFC as they host the San Francisco 49ers. Philadelphia (10-1) defeated Buffalo, 37-34 in a thrilling game on Sunday, while San Francisco (8-3) beat Seattle, 31-13 on Thanksgiving night. The teams most recently played in last January's NFC Championship Game, a 31-7 Eagles victory.

Kickoff from Lincoln Financial Field is set for 4:25 p.m. ET. San Francisco is a 3-point road favorite in the latest 49ers vs. Eagles odds via SportsLine consensus, while the over/under is 47. Before making any Philadelphia vs. San Francisco picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2023 NFL season on an incredible 175-126 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 29-18 roll on top-rated NFL picks since Week 7 of last season and is 22-8 straight-up the last two weeks.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Eagles vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Under the total, and it also says one side of the spread hits more than 50% of the time! You ABSOLUTELY need to see it before locking in your own picks. 

Who wins Eagles vs. 49ers, and which side of the spread hits more than 50% of the time? Join SportsLine right now to find out which side of the 49ers-Eagles spread is a MUST-BACK, all from the model on a 175-126 roll on NFL picks!