The San Francisco 49ers (6-10) and Arizona Cardinals (7-9) are both eliminated from the postseason heading into their final game of the season in Week 18 on Sunday. The 49ers, the defending NFC Champions, will have their three-year postseason streak snapped this season in a year plagued with injuries beginning even before the first snap. The Cardinals will miss the postseason for the third straight season and have lost five of their last six games. Joshua Dobbs will start at quarterback for the 49ers after Brock Purdy suffered an elbow injury last week.

Kickoff is set for 4:25 p.m. ET on Sunday from State Farm Stadium in Glendale, Arizona. The Cardinals are favored by 4.5 points in the latest Cardinals vs. 49ers odds, while the over/under is 42.5 points, per SportsLine consensus. 

Before entering any 49ers vs. Cardinals picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 of the 2024 NFL season on a 30-14 hot streak on top-rated NFL picks this year -- a stunning 68% success rate! Longer term, it is on a 210-142 roll on top-rated NFL picks that dates back to the 2017 season and a 64-35 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen STRONG returns!

The model has simulated 49ers vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Cardinals vs. 49ers? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.