The San Francisco 49ers look to defeat the Arizona Cardinals for the fifth straight meeting as the two NFC West rivals face off on Sunday afternoon. San Francisco (2-2) defeated New England last week, 30-13, while Arizona (1-3) fell at home to Washington, 42-14. The 49ers' offense has been plentiful over the last two seasons vs. Arizona, scoring 38, 38, 35, and 45 points when the teams have played. 

Kickoff from Levi's Stadium is set for 4:05 p.m. ET. San Francisco is a 7.5-point favorite in the latest 49ers vs. Cardinals odds, while the over/under for total points is 48.5. The 49ers are -350 money-line favorites (risk $350 to win $100). Before making any Arizona vs. San Francisco picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2024 NFL season on an incredible 188-131 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated 49ers vs. Cardinals 10,000 times and the results are in. We can tell you the model is leaning Over on the total. It also says one side of the spread hits well over 60% of the time! You ABSOLUTELY need to see what it is before locking in any NFL picks of your own!

Who wins Arizona vs. San Francisco, and which side of the spread hits in well over 60% simulations? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!