The San Francisco 49ers look to make a second half run after their bye week as they travel to the southeast to face off against the Tampa Bay Buccaneers on Sunday afternoon. San Francisco (4-4) beat Dallas, 30-24, in Week 8, while Tampa Bay (4-5) enters off an overtime loss at undefeated Kansas City, 30-24. The 49ers have won three straight games in this rivalry including a 27-14 home victory last November. San Francisco is 4-4 against the spread, while Tampa Bay is 5-4 ATS in 2024.

Kickoff from Raymond James Stadium is set for 1 p.m. ET. San Francisco is a 6-point favorite in the latest 49ers vs. Bucs odds via SportsLine consensus, while the over/under for total points is 50.5. The 49ers are -276 money line favorites (risk $276 to win $100). Before making any Tampa Bay vs. San Francisco picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

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The model has simulated 49ers vs. Bucs 10,000 times and the results are in. We can tell you the model is leaning Under on the total. It also says one side of the spread hits well over 50% of the time!

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