The Buffalo Bills (9-2) have the San Francisco 49ers (5-6) rolling into town for a primetime battle on Sunday Night Football. Buffalo has won six games in a row. In Week 11, the Bills defeated the Kansas City Chiefs 30-21. Meanwhile, the 49ers have dropped two straight games. In Week 12, the Green Bay Packers dominated San Francisco en route to a 38-10 victory.

Kickoff from Highmark Stadium in Buffalo is set for 8:20 p.m. ET. The Bills are 7-point favorites in the latest 49ers vs. Bills odds from the SportsLine Consensus, while the over/under for total points scored is 44.5. The Bills are -325 money line favorites (risk $325 to win $100), while the 49ers are +256 underdogs (risk $100 to win $256). Before making any 49ers vs. Bills picks, you NEED to see the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2024 NFL season on an incredible 22-8 hot streak on top-rated NFL picks this year. Longer term, it is on a 202-136 roll on top-rated NFL picks that dates back to the 2017 season and a 56-29 roll on top-rated NFL picks since Week 7 of 2022.

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The model has simulated 49ers vs. Bills 10,000 times and the results are in. We can tell you the model is leaning Over the point total, and it also says one side of the spread has ALL the value!

Who wins 49ers vs. Bills on Sunday Night Football, and which side of the spread has ALL the vaue? ... Join SportsLine right now to find out which side of the 49ers vs. Bills spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!