The Chicago Bears look to win their first game for interim coach Thomas Brown as they travel to the west coast to face the San Francisco 49ers on Sunday afternoon. The Bears (4-8) are losers of six straight games and fired coach Matt Eberflus following a 23-20 Thanksgiving Day loss to the Lions. The 49ers (5-7) have lost three straight games, including a 35-10 blowout to the Bills in a snowstorm last Sunday night. Chicago won the last meeting on opening day 2022, a 19-10 home victory. The Bears are 7-4-1 against the spread, while the 49ers are 4-8 ATS in 2024.

Kickoff from Levi's Stadium is set for 4:25 p.m. ET. San Francisco is a 3-point favorite in the latest 49ers vs. Bears odds via SportsLine consensus, while the over/under for total points is 44. Before making any Chicago vs. San Francisco picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 14 of the 2024 NFL season on an incredible 24-10 hot streak on top-rated NFL picks this year. Longer term, it is on a 204-138 roll on top-rated NFL picks that dates back to the 2017 season and a 58-31 roll on top-rated NFL picks since Week 7 of 2022.

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The model has simulated 49ers vs. Bears 10,000 times and the results are in. We can tell you the model is leaning Over on the total. It also says one side of the spread hits over 50% of the time!

Who wins Chicago vs. San Francisco, and which side of the spread hits over 50% of the time? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!