Almost without fail, a college basketball program on a double-digit seed line in the NCAA Tournament makes a run to at least the Sweet 16, sending countless bracket competition entries into the waste basket.

Last year, the spoiler distinction went to NC State. The Wolfpack, the No. 11 seed in the South Regional, defeated Oakland 79-73 in overtime in the second round to reach the Sweet 16. The Wolfpack's Cinderella run resulted in a Final Four berth, where they lost 63-50 to eventual runner-up Purdue. Fellow No. 11 seed Oregon came up just short of the Sweet 16 with an 86-73 double-overtime loss to Creighton.

So which double-digit seeds have the best chance of seeing the second weekend pf the 2025 NCAA Tournament, and which college basketball odds offer the highest value for correctly identifying these sleepers?

SportsLine expert Zack Cimini answers these questions below. Cimini is a longtime SportsLine college basketball analyst with a proven knack for identifying viable underdogs in the postseason. Cimini heads into the NCAA Tournament with a 68-45-3 record on his against-the-spread picks for SportsLine members, returning a profit of nearly $1,800 to his followers! You MUST see his 202 NCAA Tournament sleeper picks below before making any of your own. 

Which teams have what it takes to make a Cinderella run into the Sweet 16? And which double-digit underdog is primed for a first-round upset? Join SportsLine right now to see the top sleeper picks to reach the Sweet 16, all from the expert who is up nearly $1,800 on his college basketball picks at SportsLine!