The 2025 Australian Open tennis men's singles tournament begins on Jan. 12, with defending champion Jannik Sinner listed as the +160 favorite (risk $100 to win $160) in the 2025 Australian Open odds. He is followed by defending French Open and Wimbledon winner Carlos Alcaraz (+320), and 10-time Australian Open champion Novak Djokovic (+380).  

Alexander Zverev (11-1), Daniil Medvedev (14-1) and Taylor Fritz (28-1) are next in line on the tennis odds board. Medvedev won the 2021 US Open and has twice held a 2-0 lead in the Australian Open Final, while Fritz is coming off a runner-up finish at last year's US Open.  

Before you make any Australian Open picks or predictions, you must see the Australian Open 2025 picks from tennis handicapper Jose Onorato.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players.

Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bets. He studies current form, players' tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach has helped Onorato go 168-106-9 (+107.12 units) since 2022. In the 2024 US Open, he included Sinner (+320) in his best bets.

For the first grand slam tournament of the season, Onorato has broken down the latest odds for the men's draw of the 2025 Australian Open and has identified his futures plays.

One surprise: Onorato is fading Djokovic, even though he is a 10-time Australian Open champion. "Djokovic, historically a dominant force at the Australian Open, faces challenges this year due to fitness concerns. At 38, and coming off an injury that led him to miss the ATP Tour Finals, there are doubts about his ability to endure the rigorous fortnight of the tournament. His extensive experience always makes him a competitor, but the physical demands this year make him a riskier bet," Onorato told SportsLine. 

Onorato has thoroughly studied the men's draw and has identified multiple futures plays, including one on a longshot that would pay higher than 25-1! You ABSOLUTELY need to see what they are before locking in any 2025 Australian Open picks of your own!

So where does all the value lie in the 2025 Australian Open, and what longshot is a must-back? ... Join SportsLine right now to see Jose Onorato's predictions and analysis for the 2025 Australian Open men's draw, all from the tennis expert who is 168-106-9 since 2022!