The Week 6 college football schedule features just one ranked matchup in No. 9 Missouri vs. No. 25 Texas A&M, but it is loaded with other intriguing conference matchups. The Aggies are 2.5-point home favorites, per the Week 6 college football odds, while Washington is favored by the same line in its matchup with Michigan. Elsewhere in the Big Ten, No. 3 Ohio State is a 20.5-point favorite over Iowa, which is one of the biggest Week 6 college football spreads. Additionally, the first contest for the 2024 Commander-in-Chief's Trophy will take place with Navy vs. Air Force (+10) on Saturday at noon ET.

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