The Buffalo Bills (2-0) will host the Jacksonville Jaguars (0-2) as part of a Monday Night Football doubleheader. The Bills have won two straight games, knocking off the Miami Dolphins, 31-10 in Week 2. Meanwhile, the Jaguars have lost two straight contests. Last week, the Cleveland Browns edged out the Jaguars, 18-13. Kickoff from Highmark Stadium is set for 7:30 p.m. ET.

Buffalo is a 5.5-point favorite in the latest Jaguars vs. Bills odds, while the over/under for total points scored is 45.5. The Bills are -250 money-line favorites (risk $250 to win $100), while the Jaguars are +203 underdogs.

Before making any Jaguars vs. Bills picks or predictions of your own, you NEED to see which side SportsLine NFL expert Mike Tierney is on. 

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Mike is 154-124-9 in the NFL the past two seasons, returning $1,586 to $100 players (every bet 1 unit). Tierney also has a strong read on the Bills. He is 41-18 (+2161) on his last 59 picks in games involving Jacksonville. Anyone who has followed him is way up!

Now, Tierney has locked in another confident against-the-spread pick for Jaguars vs. Bills.

We can tell you he's leaning Over the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Jaguars vs Bills on Monday Night Football, and what X-factor makes one side a must-back? ... Join SportsLine right now to see which side of the Jaguars vs. Bills spread to back, all from an expert on a 41-18 roll on picks involving the Jaguars!