The red-hot Buffalo Bills take on the struggling San Francisco 49ers in a key Sunday Night Football matchup. San Francisco is coming off a 38-10 loss to the Green Bay Packers on Sunday, while Buffalo is coming off its bye after downing the defending Super Bowl champion Kansas City Chiefs 30-21 on Nov. 17. The 49ers (5-6), who are fourth in the NFC West but just one game out of first place, have dropped two in a row and three of five. The Bills (9-2), who are first in the AFC East, have won six consecutive games and are just one game out of the top seed in the conference.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. Buffalo is a 7-point favorite in the latest 49ers vs. Bills odds, while the over/under for total points scored is set at 44.5. The Bills are -325 money line favorites (risk $325 to win $100), while the 49ers are +256 underdogs (risk $100 to win $256).

Before making any 49ers vs. Bills picks or predictions of your own, you NEED to see which side SportsLine NFL expert Micah Roberts is on. 

Micah Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Most importantly, Roberts has a strong read on the pulse of the 49ers. In fact, he is an AMAZING 25-6 (+1838) on his last 31 picks in games involving San Francisco! Anybody following is WAY UP!

Now, Roberts has locked in another confident against-the-spread pick for 49ers vs. Bills.

We can tell you he's leaning Under the point total, but he also knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins 49ers vs. Bills on Sunday Night Football, and what x-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the 49ers vs. Bills spread hits HARD, all from the expert who is an AMAZING 25-6 on picks involving the 49ers!