Game 2 of the Monday Night Football doubleheader will feature the Seattle Seahawks (3-0) facing the Detroit Lions (2-1). Seattle is coming off a 24-3 thumping of the Miami Dolphins, while Detroit defeated the Arizona Cardinals 20-13 in Week 3. The Seahawks, who finished third in the NFC West at 9-8, are playing their first conference game of the season. The Lions, who finished 12-5 a year ago and reached the NFC Championship Game, are 2-1 against NFC foes.        

Kickoff from Ford Field in Detroit is set for 8:15 p.m. ET. Detroit is a 3.5-point favorite in the latest Seahawks vs. Lions odds, while the over/under for total points scored is 46.5. Detroit is a -189 favorite (risk $189 to win $100) on the money line, while Seattle is a +157 underdog. Before you make any Seahawks vs. Lions bets or predictions, you NEED to see which side SportsLine NFL expert Josh Nagel is on. 

Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. 

In addition, Nagel has gone 25-11 (+1345) on his last 36 picks in games involving the Seattle Seahawks! Anyone who has followed him is WAY up!

Now, Nagel has locked in another confident against-the-spread pick for Seahawks vs. Lions.

We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Seahawks vs. Lions on Monday Night Football, and what x-factor makes one side a must back? ... Join SportsLine right now to see which side of the Seahawks vs. Lions spread to back, all from the expert who is 25-11 on picks involving the Seahawks!