Only four players remain in the men's draw of the 2022 U.S. Open, with the semifinals set for Friday in New York. One of the matchups features No. 3 seed Carlos Alcaraz taking on No. 22 seed Frances Tiafoe. In addition to knocking off Rafael Nadal earlier in his run, Tiafoe defeated No. 9 seed Andrey Rublev in straight sets in the quarterfinal to advance. Alcaraz knocked off Jannik Sinner in a five-set marathon on Wednesday.

Alcaraz is the -220 favorite (risk $220 to win $100) in the latest Tiafoe vs. Alcaraz odds from Caesars Sportsbook, while Tiafoe is a +170 underdog. The over/under for total games is set at 39.5. Alcaraz is also favored by 3.5 games on the spread.

Before you lock in any Tiafoe vs. Alcaraz or 2022 U.S. Open men's semifinal picks or props, you MUST see whom Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 -- the last Australian title won by someone other than Djokovic, Rafael Nadal or Roger Federer. Calvert took down a huge score on Dominic Thiem winning the 2019 Indian Wells title at 80-1, among many stunning calls. In addition, Calvert nailed Casper Ruud making the 2022 French Open final, winning big for anyone who backed him. Sean also hit all three of his picks at plus-money odds in the Wimbledon final, including Novak Djokovic winning three sets to one at +275.

Now, Calvert has released best bets for the Tiafoe vs. Alcaraz match. We can tell you he's locked in three STRONG picks, including a plus-money play that returns almost 5-1! You ABSOLUTELY need to see all of Calvert's picks and analysis of the 2022 U.S. Open semifinal before you bet.

So who wins Tiafoe vs. Alcaraz in the 2022 U.S. Open semifinals? ... Join SportsLine right now to see Sean Calvert's top 2022 U.S. Open men's semifinal picks, all from the acclaimed expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1!