The 2022 U.S. Open begins on Monday, August 29 in New York, with a great deal of intrigue on the men's side. 21-time grand slam champion and former world No. 1 Novak Djokovic is not in the field, withdrawing due to his vaccination status and the inability to travel into the United States. However, the men's draw is packed with talent, including 2021 champion Daniil Medvedev as the No. 1 seed. The field also includes four-time U.S. Open champion Rafael Nadal and quality depth.

Medvedev is the +225 betting favorite (risk $100 to win $225) in the latest 2022 U.S. Open men's singles odds at Caesars Sportsbook. Nadal has the second-best odds at +400, followed by Carlos Alcaraz at +500. Other notables include Nick Kyrgios at +900 and Stefanos Tsitsipas at +1400 to win the grand slam title. 

Before you make any men's tennis picks on the 2022 U.S. Open, you need to see who Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 -- the last Australian title won by someone other than Djokovic, Rafael Nadal or Roger Federer. Calvert took down a huge score on Dominic Thiem winning 2019 Indian Wells title at 80-1, among many stunning calls. In addition, Calvert nailed Casper Ruud making the 2022 French Open final, winning big for anyone who backed him. Sean also nailed all three of his picks at plus-money odds in the Wimbledon final, including Djokovic winning three sets to one at +275.

Now, Calvert has pored over the latest U.S. Open odds and released his coveted best bets to win it all. We can tell you he's fading Rafael Nadal. Nadal is a 22-time grand slam winner and oddsmakers give him the second-best chance to win the tournament. But the expert has questions about his fitness and injury status, giving Calvert pause at this price.

Instead, Calvert is backing a pair of MAJOR longshots to make the final who are priced at 25-1 or higher! These players could both take advantage of easy draws to post stunning results that would cash in HUGE. You ABSOLUTELY need to see who they are before locking in any 2022 U.S. Open picks of your own!

Who wins the 2022 U.S. Open men's singles title? Which long shots could make a run at the Grand Slam title? ... Join SportsLine right now to see Sean Calvert's detailed 2022 U.S. Open picks, all from the renowned tennis expert who called Stan Wawrinka winning the Australian Open at 60-1!