The No. 3-seeded Wisconsin Badgers will take on the No. 11-seeded Iowa State Cyclones on Sunday in a Round of 32 matchup. Wisconsin snuck past No. 14 seed Colgate 67-60 on Friday while Iowa State upset No. 6 seed LSU 59-54 in the first round. Now they'll go head-to-head with a Sweet 16 spot on the line and neither program has made it to the third round since 2017.

Tipoff is set for 6:10 p.m. ET at Fiserv Forum in Milwaukee. The Badgers are four-point favorites in the latest Wisconsin vs. Iowa State odds from Caesars Sportsbook, and the Over-Under is set at 127. (Head over to our college basketball odds page for up-to-date odds on every game). 

Before you make any Iowa State vs. Wisconsin picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that Wisconsin needed a huge game from Big Ten Player of the Year Johny Davis in the first round to survive a scare from Colgate. Davis had 25 points and eight rebounds in the victory and is averaging 19.8 points and 8.2 rebounds per game for the season. Brad Davison had a quiet 1-for-5 night with four points and Wisconsin's second-leading scorer will need to provide more if Wisconsin is going to get back to the Sweet 16 for the first time since Greg Gard's first season at the helm of the program. 

The model also knows that Iowa State got some clutch shooting from Tyrese Hunter in the upset win over LSU. Hunter went 7-for-11 from the 3-point line and finished with 23 points on the night. With LSU mounting a comeback late in the game, Hunter hit a stepback 30-footer to extend the lead to five points with less than 30 seconds left and ultimately ice the game. Izaiah Brockington also had 19 points and Iowa State had 15 steals as a team to help score the bracket-busting win.

Now, the model has broken down the Wisconsin vs. Iowa State matchup from every angle and revealed its results. We can tell you the model is leaning Over on the total, and it also says one side of the spread hits in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Wisconsin vs. Iowa State in their 2022 NCAA Tournament opener? And which side of the spread hits over 50 percent of the time? ... Join SportsLine right now to find out which side of the Iowa State vs. Wisconsin spread you should be all over Sunday, all from the model on a roll on college basketball picks!