The 2022 NCAA Tournament bracket has featured plenty of upsets, but a quartet of college basketball blue bloods ultimately made the Final Four. No. 1 seed Kansas will take on No. 2 seed Villanova in the first national semifinal on Saturday at 6:09 p.m. ET. No. 2 seed Duke vs. No. 8 seed North Carolina follows at 8:49 p.m. ET. Caesars Sportsbook lists the Jayhawks as 4.5-point favorites, while the Blue Devils are -4 in the 2022 NCAA Tournament odds. 

Before making any Final Four picks for the NCAA Tournament 2022, you NEED to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, the model has evaluated the latest March Madness odds, simulated every Final Four matchup, and the results are in.

We can tell you one of the model's strongest Final Four picks is that the Over hits in Kansas vs. Villanova. The model is projecting 143 total points, as the Over clears almost 80 percent of the time.

The model has also has STRONG picks against the spread for both games, saying one team covers the spread 60 percent of the time! You ABSOLUTELY need to see its March Madness picks for every single game before locking in your own.

So which teams should you back in the Final Four? And which STRONG against the spread picks do you need to jump on now? ... Join SportsLine right now to find out who wins and covers both Final Four matchups, all from the model on a roll on college basketball picks!