The Duke Blue Devils and North Carolina Tar Heels take their storied rivalry to a new level as they meet in the NCAA Tournament for the first time when they square off in the Final Four on Saturday. The ACC adversaries split their two meetings during the regular season, with each winning on the road, but the Tar Heels own a 141-115 advantage in the all-time series. Duke (32-6), the No. 2 seed in the West Region of the 2022 NCAA Tournament, advanced by defeating Arkansas 78-69. Seeded eighth in the East Region, North Carolina (28-9) rolled past Saint Peter's 69-49 to move on.

Tip-off at the Caesars Superdome in New Orleans is set for 8:49 p.m. ET. The Blue Devils are four-point favorites in the latest Duke vs. North Carolina odds from Caesars Sportsbook, while the over-under for total points scored is 153.

Before making any North Carolina vs. Duke picks or 2022 NCAA Tournament predictions, you NEED to see what SportsLine college basketball expert Matt Severance has to say.

A well-connected writer and handicapper who has worked in the industry since 2005, Severance is on a stunning run: He is a blistering 102-71-4 on his last 177 against-the-spread picks, returning $2,379 for $100 bettors during that span. Anyone who has followed him is WAY UP!

The Blue Devils would love nothing better than to win coach Mike Krzyzewski his sixth national championship in his final season. Duke also would like to avenge the 94-81 loss to North Carolina in Krzyzewski's final home game on March 5. Freshman forward Paolo Banchero leads the Blue Devils in scoring with an average of 17.1 points and has produced 18.5 per game during the Tournament.

North Carolina has performed much better than a No. 8 seed in the "Big Dance" as it convincingly defeated three of its opponents and took out top-seeded Baylor in overtime in the second round. Armando Bacot is coming off a monster performance against Saint Peter's in the Elite Eight as he scored a game-best 20 points and matched his season high with 22 rebounds. The junior forward leads the Tar Heels with averages of 16.5 points and 12.8 boards.

Now, Severance has locked in another confident against-the-spread pick for Duke vs. North Carolina. We can tell you that he's leaning Under the total, but he knows a crucial X-factor that makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Duke vs. North Carolina in the Final Four on Saturday? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the North Carolina vs. Duke spread to jump on, all from the expert who's an outstanding 102-71-4 on his last 177 college basketball spread picks!