Rafael Nadal is after his record 21st Grand Slam title on Sunday when he takes on world No. 2 Daniil Medvedev in the 2022 Australian Open men's singles final. The sixth-seeded Nadal defeated Matteo Berrettini 6-3, 6-2, 3-6, 6-3 in Thursday night's first semifinal. No. 2 seed Medvedev secured his spot with a 7-6 (7-5), 4-6, 6-4, 6-1  victory over Stefanos Tsitsipas early Friday.

The match is set to begin Sunday at 3:30 a.m. ET. Medvedev is the -187 favorite (risk $187 to win $100) in the latest 2022 Australian Open odds from Caesars Sportsbook, while Nadal is a +160 underdog (risk $100 to win $160). The over-under for total games played is 39.5.

Before you lock in any 2022 Australian Open men's semifinals picks or props, you MUST see who Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 -- the last Australian title won by someone other than Novak Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. 

And in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat  Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130). Anyone following his picks is WAY UP!

Calvert knows that Medvedev stopped Djokovic from winning his 21st Grand Slam title in last year's U.S. Open final. The Russian also defeated Nadal in their most recent matchup, in a semifinal at the 2020 ATP Finals in London. But the expert also knows Nadal is 3-1 in his career against Medvedev, including a victory in the 2019 U.S. Open final. Nadal missed a lot of time with a foot injury last season, but he kicked off this campaign by winning the Melbourne Summer Set.

Calvert is leaning over on the game totals and he has released best bets for the Nadal vs. Medvedev match, with three STRONG options, including one of them bringing a payout around 5-1! You ABSOLUTELY need to see all of Calvert's picks and analysis of the 2022 Australian Open final before you lock in any plays of your own.

So who wins Nadal vs. Medvedev in the Australian Open men's final? And which pick could lead to a HUGE return? ... Join SportsLine right now to see Sean Calvert's top 2022 Australian Open final picks, all from the acclaimed expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1!