Novak Djokovic remains on course to make history as he prepares to face Alexander Zverev on Friday in the men's singles semifinals at the 2021 U.S. Open. Djokovic is seeking his record 21st Grand Slam title and would become the first player since Rod Laver in 1969 to win a calendar-year Slam. But first up is Zverev, who won the gold medal at the 2020 Tokyo Olympics and ranks fourth in the world. The match is scheduled to begin at 7 p.m. ET at Arthur Ashe Stadium in New York.

The latest Djokovic vs. Zverev odds from Caesars Sportsbook list Djokovic as the -225 favorite (risk $225 to win $100), while Zverev is the +210 underdog. The Over-Under for total games is set at 38.5. 

Before you make any Djokovic vs. Zverev 2021 U.S. Open men's semifinals picks, you MUST see what expert Sean Calvert has to say.

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1.

And earlier in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat Matteo Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130).

Now, Calvert has broken down the latest U.S. Open men's semifinals odds and released his coveted best bets for Djokovic vs. Zverev. He's locked in a best bet with a plus-money payout for the semifinal matchup and offers his full breakdown of the match! You ABSOLUTELY need to see Calvert's picks and analysis of Djokovic vs. Zverev and the 2021 U.S. Open before you bet.

So who wins the Djokovic vs. Zverev men's semifinal matchup on Friday? And which pick could lead to the best return? ... Join SportsLine right now to see Sean Calvert's top 2021 U.S. Open semifinal picks, all from the acclaimed expert who has crushed his tennis Grand Slam predictions!