Top seed Novak Djokovic faces a tough task Sunday as he tries to close out a record 21st Grand Slam title against second-seeded Daniil Medvedev in the men's singles final at the 2021 U.S. Open. Djokovic would become the first player since Rod Laver in 1969 to win a calendar-year Slam and break the record for major titles that he shares with Roger Federer and Rafael Nadal. Medvedev lost to Djokovic in the Australian Open final and is seeking his first major title. 

The match is scheduled for 4 p.m. ET at Arthur Ashe Stadium in New York. The latest Djokovic vs. Medvedev odds from Caesars Sportsbook list Djokovic as the -275 favorite (risk $275 to win $100), while Medvedev is the +230 underdog. The Over-Under for total games is set at 38.5. 

Before you make any Djokovic vs. Medvedev 2021 U.S. Open men's final picks, you MUST see what expert Sean Calvert has to say.

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1.

And earlier in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat Matteo Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130).

Now, Calvert has broken down the latest odds on the U.S. Open men's final and released his coveted best bets for Djokovic vs. Medvedev. He's locked in a best bet with a plus-money payout for the final and says you should strongly consider a couple of others so you can cash in even bigger! You ABSOLUTELY need to see Calvert's picks and analysis for Djokovic vs. Medvedev and the 2021 U.S. Open before you bet.

So who wins the Djokovic vs. Medvedev men's final on Sunday? And which pick could lead to the best return? ... Join SportsLine right now to see Sean Calvert's top 2021 U.S. Open final picks, all from the acclaimed expert who has crushed his tennis Grand Slam predictions!