The 2021 U.S. Open has eased into the quarterfinals at Flushing Meadows, with a pair of matches on both the men's and women's sides on Tuesday and Wednesday. Novak Djokovic is on course for a historic calendar-year Grand Slam, and his match Wednesday against Matteo Berrettini is one of the most anticipated of the tournament. It is a rematch of July's Wimbledon's men's final, which Djokovic won in four sets for his record-tying 20th Grand Slam title. The match is set to begin at 8:15 p.m. ET.

The latest Djokovic vs. Berrettini odds from Caesars Sportsbook list Djokovic as the -800 favorite (risk $800 to win $100), while Berrettini is tabbed as the +500 underdog. The Over-Under for total games is set at 33.5. 

Before you make any Djokovic vs. Berrettini 2021 U.S. Open men's quarterfinals picks, you MUST see what expert Sean Calvert has to say.

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1.

And earlier in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130).

Now, Calvert has broken down the latest U.S. Open men's quarterfinals odds and released his coveted best bets for Djokovic vs. Berrettini. He's locked in a best bet for the highly anticipated matchup and offers his full breakdown of the match! You ABSOLUTELY need to see Calvert's picks and analysis of Djokovic vs. Berrettini and the 2021 U.S. Open before you bet.

So who wins the Djokovic vs. Berrettini men's quarterfinal matchup? And which pick could lead to the best return? ... Join SportsLine right now to see Sean Calvert's top 2021 U.S. Open quarterfinal picks, all from the acclaimed expert who has crushed his tennis Grand Slam predictions!