A spot in the divisional round of the playoffs will be on the line when two AFC East rivals, the Buffalo Bills and New England Patriots, collide in a 2022 NFL Super Wild Card Weekend game on Saturday. The Bills (11-6) are coming off their second straight divisional title and enter the playoffs as the No. 3 seed in the AFC bracket. The Patriots (10-7) return to the postseason after a one-year absence and are the No. 6 seed. 

Kickoff is set for 8:15 p.m. ET on CBS. Buffalo is a five-point favorite in the latest Bills vs. Patriots odds from Caesars Sportsbook while the Over/Under for total points scored is 43.

Before making any Patriots vs. Bills picks or NFL playoff predictions, you need to see the picks from legendary handicapper Hammerin' Hank Goldberg over at SportsLine. 

A beloved national treasure, Goldberg enjoyed 15 winning seasons in his 17-year ESPN run. In 2017, Hammer competed against 10 top handicappers in the Las Vegas Review-Journal's NFL Challenge and beat them all, finishing 50-29-6 in against-the-spread picks.

He also has a keen eye for both of these teams. He is 20-11-2 (+763) in his last 33 against-the-spread picks in games involving the Bills and 18-11 (+571) in his last 29 against-the-spread picks in games involving the Patriots. Anyone who has followed him is way up.

Buffalo's Josh Allen has established himself as one of the league's top quarterbacks. The No. 7 overall pick in the 2018 NFL Draft, Allen had 42 combined passing and rushing touchdowns in the regular season; only Tom Brady (45) had more. Allen also joined Brady, Patrick Mahomes and Aaron Rodgers as the only quarterbacks to have 4,000 passing yards and 35 passing touchdowns in each of the past two seasons.

New England's Damien Harris has had success against the Bills in his career. The third-year running back from Alabama has rushed for 100 yards and scored a touchdown in each of his three career games against Buffalo. The last time he faced the Bills, Harris rushed for three touchdowns, tied for the most by a Patriots player in a game against Buffalo in franchise history.

Now, Goldberg has locked in another confident against-the-spread pick for Bills vs. Patriots. We can tell you he's leaning Under the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Bills vs. Patriots on Saturday in the 2022 NFL playoffs? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Patriots vs. Bills spread to jump on, all from the expert who's an outstanding 20-11 on NFL picks in games involving the Bills!