A number of 2021 Copa Libertadores favorites continue action during the first leg of the Round of 16 on Wednesday. Among the pre-tournament favorites to kick off action are Flamengo, River Plate and defending tournament champion Palmeiras.

Palmeiras has been installed as a -143 favorite in the Palmeiras vs. Universidad Catolica odds from William Hill Sportsbook, while Universidad Catolica is a +450 underdog. There are three additional 2021 Copa Libertadores matches set to be played on Wednesday, including Velez Sarsfield (+110) vs. Barcelona Guayaquil, River Plate (-200) vs. Argentinos Juniors and Defensa y Justicia vs. Flamengo (-120). 

Before you make any 2021 Copa Libertadores predictions, you MUST see what soccer expert Roger Gonzalez has to say.

Gonzalez grew up playing competitive soccer before becoming one of the world's foremost soccer journalists. After covering soccer all over the globe -- a Champions League final in Italy, Copa America, and professional leagues in Argentina -- Gonzalez returned to the U.S. as CBS Sports' top soccer expert. 

Now, Gonzalez has broken down the Round of 16 at the 2021 Copa Libertadores. We can tell you Gonzalez is taking the over 2.5 goals in the Palmeiras vs. Universidad Catolica matchup. "Palmeiras averaged over three goals a game in the group stage, and while Universidad Catolica doesn't light things up or concede much, the superior quality of the Brazilian side will be evident early as the reigning champs look to end this one after the first leg," Gonzalez says.

Gonzalez has four other plays, including two with a plus-money payout on the match's outcome. You ABSOLUTELY need to see his picks and analysis before you bet!

So who should you back in Wednesday's Round of 16 matchups at Copa Libertadores? And which prop bets should you be all over? ... Join SportsLine now to get Roger Gonzalez's STRONG picks for Wednesday's games, all from the soccer insider who has his finger on the pulse of South American soccer!