Top-seeded Novak Djokovic takes on sixth-seeded Alexander Zverev in the 2021 Australian Open quarterfinals. Djokovic is a -205 favorite (risk $205 to win $100), with Zverev getting +190 as the underdog.

There are plenty of ways to bet the match, however, including an Over-Under on the total games played at 41.5, and a first-set tie-break that is listed at +180. Before you lock in any 2021 Australian Open men's quarterfinals picks, you MUST see who Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is WAY UP!

Now, Calvert has released best bets for the Djokovic vs. Zverev, including a play on the outright winner and how many total games are played. You ABSOLUTELY need to see all of Calvert's picks and analysis of the 2021 Australian Open before you bet.

So who wins Djokovic-Zverev? And which pick could lead to a HUGE return? ... Join SportsLine right now to see Sean Calvert's top 2021 Australian Open quarterfinal picks, all from the acclaimed expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1! -- Use promo code TENNIS to get your first month of SportsLine for a buck!