The NFL Week 16 schedule features multiple high-profile matchups that will have significant impacts on the AFC and NFC playoff races. There are five teams favored by double-digits in the latest Week 16 NFL odds, with the Bills (-14 vs. Patriots) and Packers (-14 vs. Saints) both favored by two touchdowns. The Sunday NFL slate features 12 games, including Buccaneers (-4, 48.5) vs. Cowboys on Sunday Night Football. Among the most notable NFL matchups during the day are Commanders vs. Eagles (-3.5, 45.5) and Vikings (-3, 42.5) vs. Seahawks. 

With so many games on the Week 16 NFL schedule and parity around the league at an all-time high, finding value in the Week 16 NFL point spreads can take some extra digging.

Effectively building parlays can pay off big in your NFL betting strategy. Before making your Week 16 NFL picks and parlays, you NEED to see the Week 16 NFL parlay from SportsLine's proven computer simulation model and top rated experts that pays out well over $1.2 million for a $10 bettor. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2024 NFL season on an incredible 27-11 hot streak on top-rated NFL picks this year. Longer term, it is on a 207-139 roll on top-rated NFL picks that dates back to the 2017 season and a 61-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

For Week 16, one of the picks featured in the 7-leg parlay is Jahmyr Gibbs scoring the first touchdown in the Lions vs. Bears matchup on Sunday at +260 odds. Gibbs is set to see an increased workload in the red zone with David Montgomery sidelined with a knee injury.

The parlay also includes six other picks from the SportsLine computer simulation model, including two first touchdown scorer props that pay 10-1 or higher. The picks can all be combined for a MASSIVE payout of over $1.2 million! You ABSOLUTELY need to see these picks before locking in any NFL picks of your own.

What are the top NFL picks for Week 16 that can be combined into a parlay that returns over $1.2 million? ... Join SportsLine now to see the top Week 16 NFL picks and best bets from SportsLine's proven computer simulation model, and find out!