The 2022 American League Championship Series between the Yankees and Astros rolls on with Game 3 on Saturday evening at Minute Maid Park in Houston. First pitch is set for 5:07 p.m. ET as Houston leads the series 2-0 following a 3-2 victory in Game 2.

New York is the -155 favorite (risk $155 to win $100) on the money line in the latest Yankees vs. Astros odds from Caesars sportsbook. Houston is the +130 underdog and the over/under for total runs is set at 6.5 (see the latest lines for every game on our MLB odds page).

Before making any Yankees vs. Astros picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the league championship round on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen HUGE returns.

The model has factored in that the Yankees will turn the ball back over to Gerrit Cole, who delivered two victories for the Yankees during their ALDS win over the Guardians. Cole threw 13 1/3 innings in those two starts and only allowed three earned runs while striking out 16. Cole threw seven innings of one-run ball in a loss to the Astros on June 25 and threw seven shutout in his last ALCS start while with the Astros against the Yankees in 2019.

Meanwhile, the Astros have gotten two really strong starts from Framber Valdez and Justin Verlander to take a 2-0 series lead. Now they'll turn to Cristian Javier who had a 2.54 ERA over 148 2/3 innings with 194 strikeouts this season. The Yankees have only managed nine hits and four runs over the first two games and three of those four runs came on home runs. 

Now, it has set its sights on Astros vs. Yankees. We can tell you the model is leaning Over on the total, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Game 3 of Astros vs. Yankees? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Yankees vs. Astros run line you should be all over on Saturday, all from the model on a roll on MLB picks!