The Xavier Musketeers will wrap up their season-opening five-game homestand when they host the Siena Saints on Wednesday night. Xavier has won three of its first four games by double digits, including a 75-60 win over Wake Forest last Saturday. Siena had its three-game winning streak snapped in a 70-60 loss at Albany on Saturday, but it also picked up a win as a double-digit underdog at Bryant earlier this month.  

Tipoff is set for 6:30 p.m. ET on Wednesday at Cintas Center. Xavier is favored by 25.5 points in the latest Xavier vs. Siena odds, while the over/under is 145 points, per SportsLine consensus. Before entering any Siena vs. Xavier picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 3 of the 2024-25 season on a 156-114 roll (+1762) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Xavier vs. Siena 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Xavier vs. Siena? And which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.