After splitting a four-game series with the defending world champion Houston Astros, the Chicago White Sox will host the San Francisco Giants for their home opener on Monday in Chicago. The White Sox were tied or leading entering the sixth inning of all four games in Houston but bullpen woes led to the 2-2 start. Meanwhile, the Giants were shut out twice by the Yankees but did manage to steal a victory in Game 2 thanks to a 3-for-5 day with a home run, three RBI and a stolen base by Brandon Crawford.

First pitch is scheduled for 3:10 p.m. ET at Guaranteed Rate Field on the South Side of Chicago. Chicago is listed as a -130 favorite (risk $130 to win $100) while San Francisco is a +110 underdog on the money line in the latest White Sox vs. Giants odds from Caesars Sportsbook, while the over/under for total runs scored is 8.5 (see the latest lines for every game on our MLB odds page).

Before making any Giants vs. White Sox picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed it has seen profitable returns!

The model knows San Francisco is expected to send Anthony DeSclafani to the mound. Two seasons ago, DeSclafani went 13-7 with a 3.17 ERA and led the National League with two shutouts but he was only able to make five starts in 2022 because of a right ankle injury. However, he'll need some run support from a Giants lineup that has struggled in the first three games of the season. San Francisco is only hitting .194 as a team this season and all seven of the runs the Giants have scored came in the Game 2 win over the Yankees.

The model also knows Chicago will turn to Michael Kopech as its fifth starter in 2023. Kopech posted a 3.54 ERA over 25 starts last season and the former top-20 prospect utilizes a big fastball with plenty of ride that he backs up with a tight-breaking slider. However, the White Sox have had the second-worst bullpen in baseball thus far, as they posted an 8.25 ERA. Luckily, Chicago has gotten some solid contributions from stars like Yasmani Grandal, Tim Anderson and Yoan Moncada, who all have an OPS of at least .950 on the season.

Now, it has set its sights on White Sox vs. Giants. We can tell you the model is leaning Under on the total, projecting 8.1 combined runs, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins White Sox vs. Giants? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Giants vs. White Sox money line you should be all over on Monday, all from the model that finished on a 20-14 roll on top-rated MLB money-line picks in 2022!