The ACC and Big 12 collide when the North Carolina Tar Heels and West Virginia Mountaineers square off in the 2023 Duke's Mayo Bowl at Bank of America Stadium in Charlotte, N.C. The Tar Heels (8-4) tied for sixth in the ACC. Meanwhile the Mountaineers (8-4) were one of the pleasant surprises in college football this season, tying for fourth in the Big 12.

Kickoff is scheduled for 5:30 p.m. ET. The Mountaineers are 6.5-point favorites in the latest West Virginia vs. North Carolina odds, while the over/under for total points scored is 56.5. Before making any North Carolina vs. West Virginia picks of your own, you need to see whom Mike Tierney is picking, given his mastery of picks in games involving North Carolina.

The veteran sportswriter, whose work has appeared in The New York Times and Los Angeles Times, has covered college football of all levels for decades. 

More importantly, Tierney has a read on the pulse of the Tar Heels. He is a perfect 10-0 on his last 10 picks in games involving North Carolina. 

Tierney knows that the Mountaineers will be facing a North Carolina team that will be without starting quarterback Drake Maye. The 6-foot-4, 230-pound sophomore from Huntersville, N.C., has opted to sit out the bowl game to prepare for the NFL Draft. The loss of Maye is significant as he was a finalist for the Manning Award and is widely regarded as a top-two pick in the draft.

But Tierney also has taken into account that the Tar Heels have one of the best running backs in the country in Omarion Hampton. A 6-foot, 220-pound sophomore from Clayton, N.C., Hampton averages 120.2 rushing yards per game, which ranks third in the nation, behind only Missouri's Cody Schrader and Oklahoma State's Ollie Gordon. For his efforts this season, Hampton was named a Walter Camp first team All-America.

For Wednesday, Tierney has locked in on the Duke's Mayo Bowl and West Virginia vs. North Carolina. We can tell you he's leaning Over the point total and he's found a critical X-factor that has him jumping all over one side of the spread. You NEED to see his analysis before locking in any North Carolina vs. West Virginia picks of your own.

Who wins West Virginia vs. North Carolina on Wednesday? And what critical X-factor makes one side of the spread hit? ... Join SportsLine right now to see which side of the North Carolina vs. West Virginia spread you need to jump on, all from the expert on a perfect 10-0 run on picks involving the Tar Heels!